Publications

For questions about institutional access, please email Prof. Ondrus

2024

Nguyen A, Ondrus AE*. In silico tools to score and predict cholesterol-protein interactions. J Med Chem, 2024. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01885

Kremiller KM, Kulkarni GC, Harris LM, Gunasekara H, Kashyap Y, Ilktach G, Nguyen A, Ondrus AE, Hu YS, Wang ZJ, Riley AP*, Peters CJ*. Discovery of antinociceptive α9α10 Nicotinic Acetylcholine Receptor antagonists by stable receptor expression. ACS Chem Biol, 2024. https://pubs.acs.org/doi/10.1021/acschembio.4c00330

2023

Vo A-DP, Kim S-K, Yang MY, Ondrus AE*, Goddard WA III*. Fully activated structure of the sterol-bound Smoothened GPCR-Gi protein complex. PNAS, 2023. https://doi.org/10.1073/pnas.2300919120

Leach AR*, Ondrus AE*. Editorial overview: Restructuring drug design and development. Curr Opin Struct Biol, 2023. https://doi.org/10.1016/j.sbi.2023.102727

2022

Feng Z, Hom ME, Bearrood TE, Rosenthal ZC, Fernández D, Ondrus AE, Gu Y, McCormick AK, Tomaske MG, Marshall CR, Kline T, Chen CH, Mochly-Rosen D, Kuo CJ, Chen JK. Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1. Nat Chem Biol, 2022. https://doi.org/10.1038/s41589-022-01048-w

Mendoza M, Tran U, Zhang GC, Leister J, To K, Malepeai-Tofaeono T, Ondrus AE*, Billingsley KL*. Indolactam dipeptides as nanomolar Gli inhibitors. ACS Med Chem Lett, 2022. https://doi.org/10.1021/acsmedchemlett.1c00562

2021

Cheng Y-S, Zhang T, Ma X, Pratuangtham S, Zhang GC, Ondrus AA, Mafi A, Lomenick B, Jones JJ, Ondrus AE*. A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes. Nature Chem Biol, 2021. https://doi.org/10.1038/s41589-021-00907-2

Highlighted in News & Views by Yu W, Baskin JM. “There is a lock for every key” Nature Chem Biol, 2021.
Summary by Trauner D, Impastato AC. “Identifying the long sought-after ligand of the sigma-2 receptor” Synfacts, 2022.
Commentary by Lowe D. “Another orphan reunited” In the pipeline – Science|AAAS blog, 2021.

Zhang T, Ondrus AE*. Structure, bonding, and photoaffinity labeling applications of dialkyldiazirines. Synlett, 2021. https://doi:10.1055/a-1437-8202

Mafi A, Purohit R, Vielmas E, Lauinger AR, Lam B, Cheng Y-S, Zhang T, Huang Y, Kim S-K, Goddard WA*, and Ondrus AE*. Hedgehog proteins create a dynamic cholesterol interface. PLOS One, 2021. https://doi.org/10.1371/journal.pone.0246814

2020

Purohit R, Peng DS, Vielmas E, Ondrus AE*. Dual roles for the Sterol Recognition Region in Hedgehog protein modification. Commun Biol, 2020. https://doi.org/10.1038/s42003-020-0977-2

Tran U, Zhang G, Eom R, Billingsley KL*, Ondrus AE*. Small molecule intervention in a protein kinase C-Gli transcription factor axis. ACS Chem Bio, 2020. https://doi.org/10.1021/acschembio.0c00355

Hom ME,¹ Ondrus AE,¹ Sakata‐Kato T, Rack PG, Chen JK. Bicyclic imidazolium inhibitors of Gli transcription factor activity. ChemMedChem, 2020. ¹co-first authors. https://doi.org/10.1002/cmdc.202000169

2017

Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. Chemical structure-guided design of dynapyrazoles, potent cell-permeable dynein inhibitors with a unique mode of action. eLife, 2017. https://doi.org/10.7554/eLife.25174.001

2012

Ondrus AE,¹ Lee HL,¹ Iwanaga S, Parsons WH, Andresen BM, Moerner WE, Du Bois J. Fluorescent saxitoxins for live cell imaging of single voltage-gated sodium ion channels beyond the optical diffraction limit. Chem Biol, 2012. ¹co-first authors. https://www.doi.org/10.1016/j.chembiol.2012.05.021

2010

Ondrus AE, Kaniskan HU, Movassaghi M. Dimerization of functional pyrroloindolizines for the synthesis of complex myrmicarin alkaloids. Tetrahedron, 2010. https://www.doi.org/10.1016/j.tet.2010.04.006

2009

Ondrus AE, Movassaghi M. Total synthesis and study of myrmicarin alkaloids. Chem Commun, 2009. https://www.doi.org/10.1039/b903995n

Ondrus AE, Movassaghi M. Reversible dimerization of (+)-myrmicarin 215B. Org Lett, 2009. https://www.doi.org/10.1021/ol9008552

2008

Guggenheim ER, Ondrus AE, Movassaghi M, Lippard SJ. Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA. Bioorg Med Chem, 2008. https://www.doi.org/10.1016/j.bmc.2008.09.074

2007

Movassaghi M, Ondrus AE, Chen B. Efficient and stereoselective dimerization of pyrroloindolizine derivatives inspired by a hypothesis for the biosynthesis of complex myrmicarin alkaloids. J Org Chem, 2007. https://doi.org/10.1021/jo701981q

2006

Ondrus AE, Movassaghi M. Dimerization of (+)-Myrmicarin 215B. A potential biomimetic approach to complex myrmicarin alkaloids. Tetrahedron, 2006. https://www.doi.org/10.1016/j.tet.2006.01.108

2005

Movassaghi M, Ondrus AE. Palladium-catalyzed synthesis of N-vinyl pyrroles and indoles. J Org Chem, 2005. https://doi.org/10.1021/jo051450i

Movassaghi M, Ondrus AE. Enantioselective total synthesis of tricyclic myrmicarin alkaloids. Org Lett, 2005. https://doi.org/10.1021/ol051629f